Search results for "energy substrates"

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Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!

2012

International audience; During brain development, there is a progressive reduction of intracellular chloride associated with a shift in GABA polarity: GABA depolarizes and occasionally excites immature neurons, subsequently hyperpolarizing them at later stages of development. This sequence, which has been observed in a wide range of animal species, brain structures and preparations, is thought to play an important role in activity-dependent formation and modulation of functional circuits. This sequence has also been considerably reinforced recently with new data pointing to an evolutionary preserved rule. In a recent ``Hypothesis and Theory Article,'' the excitatory action of GABA in early …

GABA; giant depolarizing potentials; energy substrates; brain slices; chloride homeostasis; developmentBrain developmentchloride homeostasisPolarity (physics)energy substratesBiologylcsh:RC321-57103 medical and health sciencesCellular and Molecular NeuroscienceGABA0302 clinical medicineGiant depolarizing potentialsNeuronal damageAnimal speciesDevelopmental neurobiologybooklcsh:Neurosciences. Biological psychiatry. Neuropsychiatrydevelopment030304 developmental biology0303 health sciencesbrain slicesHypothesis and Theory Articledevelopment.Excitatory postsynaptic potentialbook.journal[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]giant depolarizing potentialsNeuroscience030217 neurology & neurosurgeryNeuroscience
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